反應簡介
傅-克?；磻侵敢活愒诼芬姿顾嶙鳛榇呋瘎┑臈l件下，芳烴與酰氯或酸酐進行?；姆磻?。該反應由于羰基吸電子效應的影響，一般不會像烷基化反應生成多重?；a物，僅通過親電芳香取代形成單?；a物。[1,2]
圖1. 傅-克?；磻?/p>
反應機理
Ⅰ. 路易斯酸催化劑（AlCl3）和?；穆仍有纬山j合物，氯的解離形成?；颊x子。
Ⅱ. ?；x子（RCO+）繼續對芳環進行繼續對芳烴進行親電攻擊。隨著絡合物的形成，其芳香性暫時消失。
Ⅲ. 中間態去質子化，恢復芳環的芳香性。電荷轉移至氯離子形成HCl，AlCl3催化劑重新形成。[1]
圖2. AlCl3傅-克?；磻獧C理
應用
傅-克?；磻蓱糜谝韵禄衔锏暮铣桑?/p>
1. 二芳基乙酸衍生物[4]
2. 聚醚醚酮（PEEK）或mPEK[5]
3. 1,5-雙（4-氟苯甲?；?2,6-二甲基萘[6]
4. 芳香酮[7]
5. 不對稱芳香胺[8]
6. 環酮，例如1-四烯酮和1-茚滿酮[9]
7. 2-乙?；?6-甲氧基萘，用于合成非甾體抗炎鎮痛新藥萘普生及萘普酮的關鍵中間體[10]
研究進展
1.PVP-TfOH已經作為傅-克?；磻懈咝乙子诤筇幚淼墓腆w超強酸催化劑體系得以應用。在溫和的反應條件下，芳烴和乙醛酸通過傅-克?；磻?，實現了無溶劑一鍋法合成二芳基乙酸衍生物。[4]
圖3. 芳烴和乙醛酸通過傅-克?；磻?，無溶劑一鍋法合成二芳基乙酸衍生物
2. 一種基于咪唑的離子液體可作為催化劑，催化芳烴與乙酰氯進行傅-克?；磻?。[11]
3. 據報道，三氟甲磺酸鉺是一種含有給電子基團且可用于微波輔助下芳烴的傅-克?；母咝Т呋瘎?。[12]
4. 虎皮楠生物堿是一類結構高度復雜多樣的三萜類生物堿，可通過分子內的傅-克?；磻苯忧铱焖俚臉嫿ㄆ?/span>ACDE環系統。[13]
5. 酸催化的的多米諾傅-克?；磻?，可用于高效構建臺灣杉醌的6,5,6-ABC三環骨架結構。還可用于二萜(±)-甲萘醌B和(±)-二氯酮的合成。[14]
6. 通過親電傅克?；s聚反應可合成兩種含1,4-萘單元的單體，新型聚（芳基酮）和聚（芳基醚酮砜）。[15]
7. 據研究，SBA-15中三苯基錫的甲苯和乙酸酐可發生傅-克?；磻?。[16]
8. 離子液體1-異丁基-3-甲基咪唑二氫磷酸([i-BMIM]H2PO4)中的三氟甲磺酸銦在芳香族化合物與酸酐的傅-克?；磻酗@示出強力的催化活性。[17]
9. 25,27-二烷氧基杯芳烴的傅-克?；磻?。使用酰氯和AlCl3在1,2-二氯乙烷中直接?；撌宥』紵N，以高產率區域選擇性地提供相應的二?；苌?。[18]
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